Publikationen

2024

D. Geist, G. S. Hones, S. C. Grund, J. Pape, D. Siemes, P. Spangenberg, E. Tolstik, S. Dorr, N. Spielmann, H. Fuchs, V. Gailus-Durner, M. Angelis, J. Mittag, D. R. Engel, D. Fuhrer, K. Lorenz, and L. C. Moeller,
Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice, Thyroid , 2024.
DOI:10.1089/thy.2023.0683
File: 38757582
A. M. Naujack, C. Krause, J. H. Britsemmer, N. Taege, J. Mittag, and H. Kirchner,
Epigenetic regulation of thyroid hormone action in human metabolic dysfunction associated steatohepatitis, Eur Thyroid J , 2024.
DOI:10.1530/ETJ-24-0080
File: 39189972
S. C. Sentis, R. Dore, R. Oelkrug, B. Kolms, K. A. Iwen, and J. Mittag,
Hypothalamic Thyroid Hormone Receptor alpha1 Signaling Controls Body Temperature, Thyroid , 2024.
DOI:10.1089/thy.2023.0513
File: 38149585
J. Maier, R. Dore, R. Oelkrug, A. Glatzel, A. L. Cremer, S. Binder, M. Schwaninger, H. Oster, H. Backes, and J. Mittag,
Inhibition of Thyroid Hormone Signaling in the Zona Incerta Alters Basal Metabolic Rate, Behavior and Serum Glucocorticoids in Male Mice, Thyroid , 2024.
DOI:10.1089/thy.2024.0209
File: 39189416
R. Dore, S. C. Sentis, K. Johann, N. Lopez Alcantara, J. Resch, A. Chandrasekar, H. Muller-Fielitz, L. C. Moeller, D. Fuhrer, M. Schwaninger, B. Obermayer, R. Opitz, and J. Mittag,
Partial resistance to thyroid hormone-induced tachycardia and cardiac hypertrophy in mice lacking thyroid hormone receptor beta, Thyroid , 2024.
DOI:10.1089/thy.2023.0638
File: 38526409
S. Asaad, T. S. Chillon, D. Filipowicz, B. Wilms, F. Strenge, E. Szczepanek-Parulska, W. B. Minich, S. M. Meyhofer, J. U. Marquardt, J. Mittag, H. Oster, M. Ruchala, and L. Schomburg,
Serum CD5L as potential biomarker of thyroid hormone status during pregnancy, Biofactors , 2024.
DOI:10.1002/biof.2123
File: 39345206
R. Dore, and J. Mittag,
Thyroid Hormone Receptors in Control of Heart Rate, Endocrinology , vol. 165, no. 9, 2024.
DOI:10.1210/endocr/bqae093
File: 39047059
L. V. M. Assis, L. Harder, J. T. Lacerda, R. Parsons, M. Kaehler, I. Cascorbi, I. Nagel, O. Rawashdeh, J. Mittag, and H. Oster,
Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice, Sci Rep , vol. 14, no. 1, pp. 640, 2024.
DOI:10.1038/s41598-023-50374-z
File: 38182610
H. Kerp, J. Gassen, S. C. Grund, G. S. Hones, S. Dorr, J. Mittag, N. Harting, F. Kaiser, L. C. Moeller, K. Lorenz, and D. Fuhrer,
Cardiac recovery from pressure overload is not altered by thyroid hormone status in old mice, Front Endocrinol (Lausanne) , vol. 15, pp. 1339741, 2024.
DOI:10.3389/fendo.2024.1339741
File: 38455657

2023

V. K. A. Sreenivasan, R. Dore, J. Resch, J. Maier, C. Dietrich, J. Henck, S. Balachandran, J. Mittag, and M. Spielmann,
Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development, Development , vol. 150, no. 3, 2023.
DOI:10.1242/dev.201228
File: 36715020
L. Roth, K. Johann, G. S. Hones, R. Oelkrug, L. Wagner, A. Hoffmann, K. Krohn, L. C. Moeller, J. Weiner, J. T. Heiker, N. Kloting, A. Tönjes, M. Stumvoll, M. Blüher, J. Mittag, and K. Krause,
Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action, Cell Rep , vol. 42, no. 2, pp. 112088, 2023.
DOI:10.1016/j.celrep.2023.112088
File: 36753417
R. Dore, L. Watson, S. Hollidge, C. Krause, S. C. Sentis, R. Oelkrug, C. Geissler, K. Johann, M. Pedaran, G. Lyons, N. Lopez-Alcantara, J. Resch, F. Sayk, K. A. Iwen, A. Franke, T. J. Boysen, J. W. Dalley, K. Lorenz, C. Moran, K. L. Rennie, A. Arner, H. Kirchner, K. Chatterjee, and J. Mittag,
Resistance to thyroid hormone induced tachycardia in RTHalpha syndrome, Nat Commun , vol. 14, no. 1, pp. 3312, 2023.
DOI:10.1038/s41467-023-38960-1
File: 37286550
N. Lopez-Alcantara, R. Oelkrug, S. C. Sentis, H. Kirchner, and J. Mittag,
Lack of thyroid hormone receptor beta is not detrimental for non-alcoholic steatohepatitis progression, iScience , vol. 26, no. 10, pp. 108064, 2023.
DOI:10.1016/j.isci.2023.108064
File: 37822510
R. Oelkrug, L. Harder, M. Pedaran, A. Hoffmann, B. Kolms, J. Inderhees, S. Gachkar, J. Resch, K. Johann, O. Johren, K. Krause, and J. Mittag,
Maternal thyroid hormone receptor beta activation in mice sparks brown fat thermogenesis in the offspring, Nat Commun , vol. 14, no. 1, pp. 6742, 2023.
DOI:10.1038/s41467-023-42425-w
File: 37875497

2022

S. M. Sundaram, A. Arrulo Pereira, H. Muller-Fielitz, H. Kopke, M. De Angelis, T. D. Muller, H. Heuer, J. Korbelin, M. Krohn, J. Mittag, R. Nogueiras, V. Prevot, and M. Schwaninger,
Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency, Brain , 2022.
DOI:10.1093/brain/awac243
File: 35929549
L. V. M. Assis, L. Harder, J. T. Lacerda, R. Parsons, M. Kaehler, I. Cascorbi, I. Nagel, O. Rawashdeh, J. Mittag, and H. Oster,
Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation, Elife , vol. 11, 2022.
DOI:10.7554/eLife.79405
File: 35894384
E. Rial-Pensado, V. Rivas-Limeres, C. Grijota-Martinez, A. Rodriguez-Diaz, V. Capelli, O. Barca-Mayo, R. Nogueiras, J. Mittag, C. Dieguez, and M. Lopez,
Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis, Front Physiol , vol. 13, pp. 1017381, 2022.
DOI:10.3389/fphys.2022.1017381
File: 36467699
R. Oelkrug, and J. Mittag,
Too much too soon - Tissue-specific inactivation of deiodinase type 3 prematurely exposes brown fat to thyroid hormone, Endocrinology , 2022.
DOI:10.1210/endocr/bqac032
File: 35294005
G. S. Hones, N. Harting, J. Mittag, and F. J. Kaiser,
TRalpha2-An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?, Int J Mol Sci , vol. 23, no. 13, 2022.
DOI:10.3390/ijms23136998
File: 35806002

2021

V. Capelli, C. Grijota-Martinez, N. R. V. Dragano, E. Rial-Pensado, J. Ferno, R. Nogueiras, J. Mittag, C. Dieguez, and M. Lopez,
Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase, Nutrients , vol. 13, no. 12, 2021.
DOI:10.3390/nu13124204
File: 34959756
V. Capelli, C. Dieguez, J. Mittag, and M. Lopez,
Thyroid wars: the rise of central actions, Trends Endocrinol Metab , 2021.
DOI:10.1016/j.tem.2021.05.006
File: 34294513
E. Milbank, N. R. V. Dragano, I. Gonzalez-Garcia, M. R. Garcia, V. Rivas-Limeres, L. Perdomo, G. Hilairet, F. Ruiz-Pino, P. Mallegol, D. A. Morgan, R. Iglesias-Rey, C. Contreras, L. Vergori, J. Cunarro, B. Porteiro, A. Gavalda-Navarro, R. Oelkrug, A. Vidal, J. Roa, T. Sobrino, F. Villarroya, C. Dieguez, R. Nogueiras, C. Garcia-Caceres, M. Tena-Sempere, J. Mittag, M. Carmen Martinez, K. Rahmouni, R. Andriantsitohaina, and M. Lopez,
Small extracellular vesicle-mediated targeting of hypothalamic AMPKalpha1 corrects obesity through BAT activation, Nat Metab , vol. 3, no. 10, pp. 1415-1431, 2021.
DOI:10.1038/s42255-021-00467-8
File: 34675439
S. C. Sentis, R. Oelkrug, and J. Mittag,
Thyroid hormones in the regulation of brown adipose tissue thermogenesis, Endocr Connect , vol. 10, no. 2, pp. R106-R115, 2021.
DOI:10.1530/EC-20-0562
File: 33491659
M. Pedaran, R. Oelkrug, Q. Sun, J. Resch, L. Schomburg, and J. Mittag,
Maternal thyroid hormone programs cardiovascular functions in the offspring, Thyroid , 2021.
DOI:10.1089/thy.2021.0275
File: 34269617
J. Weiner, L. Roth, M. Kranz, P. Brust, A. Boelen, N. Kloting, J. T. Heiker, M. Blüher, A. Tönjes, P. T. Pfluger, M. Stumvoll, J. Mittag, and K. Krause,
Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels, Mol Metab , vol. 54, pp. 101348, 2021.
DOI:10.1016/j.molmet.2021.101348
File: 34610354
Z. M. Li, M. Miller, S. Gachkar, J. Mittag, S. C. Schriever, P. T. Pfluger, K. W. Schramm, and M. De Angelis,
Determination of 3-iodothyronamine (3-T1AM) in mouse liver using liquid chromatography-tandem mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci , vol. 1165, pp. 122553, 2021.
DOI:10.1016/j.jchromb.2021.122553
File: 33503577
R. Oelkrug, and J. Mittag,
An improved method for the precise unravelment of non-shivering brown fat thermokinetics, Sci Rep , vol. 11, no. 1, pp. 4799, 2021.
DOI:10.1038/s41598-021-84200-1
File: 33637831

2020

S. Nock, K. Johann, L. Harder, E. K. Wirth, K. Renko, C. S. Hoefig, V. Kracke, J. Hackler, B. Engelmann, M. Rauner, J. Kohrle, L. Schomburg, G. Homuth, U. Volker, G. Brabant, and J. Mittag,
CD5L Constitutes a Novel Biomarker for Integrated Hepatic Thyroid Hormone Action, Thyroid , vol. 30, no. 6, pp. 908-923, 2020.
DOI:10.1089/thy.2019.0635
File: 32183611
B. Herrmann, L. Harder, R. Oelkrug, J. Chen, S. Gachkar, S. Nock, J. Resch, M. Korkowski, H. Heuer, and J. Mittag,
Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia, Thyroid , 2020.
DOI:10.1089/thy.2019.0705
File: 32188347
S. Mehl, Q. Sun, C. L. Gorlich, J. Hackler, J. F. Kopp, K. Renko, J. Mittag, T. Schwerdtle, and L. Schomburg,
Cross-sectional analysis of trace element status in thyroid disease, J Trace Elem Med Biol , vol. 58, pp. 126430, 2020.
DOI:10.1016/j.jtemb.2019.126430
File: 31835129
F. M. Raffaelli, J. Resch, R. Oelkrug, K. A. Iwen, and J. Mittag,
Dopamine receptor D1- and D2-agonists do not spark brown adipose tissue thermogenesis in mice, Sci Rep , vol. 10, no. 1, pp. 20203, 2020.
DOI:10.1038/s41598-020-77143-6
File: 33214601
R. Oelkrug, C. Krause, B. Herrmann, J. Resch, S. Gachkar, A. T. El Gammal, S. Wolter, O. Mann, H. Oster, H. Kirchner, and J. Mittag,
Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring, Cell Rep , vol. 33, no. 5, pp. 108351, 2020.
DOI:10.1016/j.celrep.2020.108351
File: 33147454
J. Mittag,
More Than Fever - Novel Concepts in the Regulation of Body Temperature by Thyroid Hormones, Exp Clin Endocrinol Diabetes , vol. 128, no. 6-07, pp. 428-431, 2020.
DOI:10.1055/a-1014-2510
File: 31652476
S. Gachkar, R. Oelkrug, B. Herrmann, T. S. Scanlan, Q. Sun, H. Biebermann, C. S. Hoefig, L. Schomburg, and J. Mittag,
N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice, Eur Thyroid J , vol. 9, no. 2, pp. 57-66, 2020.
DOI:10.1159/000504887
File: 32257954
R. Dore, R. Krotenko, J. P. Reising, L. Murru, S. M. Sundaram, A. Di Spiezio, H. Muller-Fielitz, M. Schwaninger, O. Johren, J. Mittag, M. Passafaro, M. Shanabrough, T. L. Horvath, A.S. Schulz, and H. Lehnert,
Nesfatin-1 decreases the motivational and rewarding value of food, Neuropsychopharmacology , 2020.
DOI:10.1038/s41386-020-0682-3
File: 32353862
S. Nock, C. Hofig, L. Harder, L. Schomburg, G. Brabant, and J. Mittag,
Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers, Exp Clin Endocrinol Diabetes , vol. 128, no. 6-07, pp. 473-478, 2020.
DOI:10.1055/a-1012-8484
File: 31590191

2019

K. Johann, A. L. Cremer, A. W. Fischer, M. Heine, E. R. Pensado, J. Resch, S. Nock, S. Virtue, L. Harder, R. Oelkrug, M. Astiz, G. Brabant, A. Warner, A. Vidal-Puig, H. Oster, A. Boelen, M. Lopez, J. Heeren, J. W. Dalley, H. Backes, and J. Mittag,
Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption, Cell Rep , vol. 27, no. 11, pp. 3385-3400 e3, 2019.
DOI:10.1016/j.celrep.2019.05.054
File: 31189119
S. Gachkar, S. Nock, C. Geissler, R. Olkrug, K. Johann, J. Resch, A. Rahman, A. Arner, H. Kirchner, and J. Mittag,
Aortic Effects of Thyroid Hormone in Male Mice, J Mol Endocrinol , 2019.
DOI:10.1530/JME-18-0217
File: 30608905

2018

J. Braunig, S. Mergler, S. Jyrch, C. S. Hoefig, M. Rosowski, J. Mittag, H. Biebermann, and N. Khajavi,
3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines, Front Endocrinol (Lausanne) , vol. 9, pp. 523, 2018.
DOI:10.3389/fendo.2018.00523
File: 30298050
K. Johann, M. C. Reis, L. Harder, B. Herrmann, S. Gachkar, J. Mittag, and R. Oelkrug,
Effects of sildenafil treatment on thermogenesis and glucose homeostasis in diet-induced obese mice, Nutr Diabetes , vol. 8, no. 1, pp. 9, 2018.
DOI:10.1038/s41387-018-0026-0
File: 29549244
L. Harder, N. Schanze, A. Sarsenbayeva, F. Kugel, J. Kohrle, L. Schomburg, J. Mittag, and C. S. Hoefig,
In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice, Eur Thyroid J , vol. 7, no. 1, pp. 3-12, 2018.
DOI:10.1159/000481856
File: 29594048
M. Hirose, P. Schilf, Y. Gupta, K. Zarse, A. Kunstner, A. Fahnrich, H. Busch, J. Yin, M. N. Wright, A. Ziegler, M. Vallier, M. Belheouane, J. F. Baines, D. Tautz, K. Johann, R. Oelkrug, J. Mittag, H. Lehnert, A. Othman, O. Johren, M. Schwaninger, C. Prehn, J. Adamski, K. Shima, J. Rupp, R. Hasler, G. Fuellen, R. Kohling, M. Ristow, and S. M. Ibrahim,
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice, Sci Rep , vol. 8, no. 1, pp. 5872, 2018.
DOI:10.1038/s41598-018-24290-6
File: 29651131
L. Harder, S. Dudazy-Gralla, H. Muller-Fielitz, J. Hjerling Leffler, B. Vennstrom, H. Heuer, and J. Mittag,
Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area, J Neuroendocrinol , vol. 30, no. 3, pp. e12573, 2018.
DOI:10.1111/jne.12573
File: 29377458
C. Krause, M. Grohs, A. El Gammal, S. Wolter, H. Lehnert, O. Mann, J. Mittag, and H. Kirchner,
Reduced expression of thyroid hormone receptor beta in human nonalcoholic steatohepatitis, Endocr Connect , 2018.
DOI:10.1530/EC-18-0499
File: 30496129
J. Braunig, J. Dinter, C. S. Hofig, S. Paisdzior, M. Szczepek, P. Scheerer, M. Rosowski, J. Mittag, G. Kleinau, and H. Biebermann,
The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor, Front Pharmacol , vol. 9, pp. 222, 2018.
DOI:10.3389/fphar.2018.00222
File: 29593543

2017

N. Schanze, S. F. Jacobi, E. Rijntjes, S. Mergler, M. Del Olmo, C. S. Hoefig, N. Khajavi, I. Lehmphul, H. Biebermann, J. Mittag, and J. Kohrle,
3-Iodothyronamine Decreases Expression of Genes Involved in Iodide Metabolism in Mouse Thyroids and Inhibits Iodide Uptake in PCCL3 Thyrocytes, Thyroid , vol. 27, no. 1, pp. 11-22, 2017.
DOI:10.1089/thy.2016.0182
File: 27788620
S. Gachkar, R. Oelkrug, N. Martinez-Sanchez, E. Rial-Pensado, A. Warner, C. S. Hoefig, M. Lopez, and J. Mittag,
3-Iodothyronamine Induces Tail Vasodilation Through Central Action in Male Mice, Endocrinology , vol. 158, no. 6, pp. 1977-1984, 2017.
DOI:10.1210/en.2016-1951
File: 28368510
R. Oelkrug, B. Herrmann, C. Geissler, L. Harder, C. Koch, H. Lehnert, H. Oster, H. Kirchner, and J. Mittag,
Dwarfism and insulin resistance in male offspring caused by alpha1-adrenergic antagonism during pregnancy, Mol Metab , vol. 6, no. 10, pp. 1126-1136, 2017.
DOI:10.1016/j.molmet.2017.06.016
File: 29031714
N. Martinez-Sanchez, P. Seoane-Collazo, C. Contreras, L. Varela, J. Villarroya, E. Rial-Pensado, X. Buque, I. Aurrekoetxea, T. C. Delgado, R. Vazquez-Martinez, I. Gonzalez-Garcia, J. Roa, A. J. Whittle, B. Gomez-Santos, V. Velagapudi, Y. C. L. Tung, D. A. Morgan, P. J. Voshol, P. B. Morentin, T. Lopez-Gonzalez, L. Linares-Pose, F. Gonzalez, K. Chatterjee, T. Sobrino, G. Medina-Gomez, R. J. Davis, N. Casals, M. Oresic, A. P. Coll, A. Vidal-Puig, J. Mittag, M. Tena-Sempere, M. M. Malagon, C. Dieguez, M. L. Martinez-Chantar, P. Aspichueta, K. Rahmouni, R. Nogueiras, G. Sabio, F. Villarroya, and M. Lopez,
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance, Cell Metab , vol. 26, no. 1, pp. 212-229 e12, 2017.
DOI:10.1016/j.cmet.2017.06.014
File: 28683288
H. Muller-Fielitz, M. Stahr, M. Bernau, M. Richter, S. Abele, V. Krajka, A. Benzin, J. Wenzel, K. Kalies, J. Mittag, H. Heuer, S. Offermanns, and M. Schwaninger,
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis, Nat Commun , vol. 8, no. 1, pp. 484, 2017.
DOI:10.1038/s41467-017-00604-6
File: 28883467
R. Dore, L. Levata, S. Gachkar, O. Johren, J. Mittag, H. Lehnert, and A.S. Schulz,
The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system, J Endocrinol , vol. 235, no. 2, pp. 111-122, 2017.
DOI:10.1530/JOE-17-0151
File: 28851749